Endocrine Abstracts

Endometrial hyperplasia has been reported in up to 15% of transmen. For this reason the current clinical practice suggest that the uterus should be scanned every 2 years.This is the single centre retrospective audit study at the largest UK Gender Identity Clinic to examine the incidence of endometrial hyperplasia in transmen.Between 2006 and 2012. 200 patients having been maintained on testosterone therapy for 2 years, of those 108...

Introduction: Microparticles (MP) are circulating submicron particles released from cell membranes. They have an important role in intercellular endocrine signalling and may be increased in numerous conditions including cardiovascular disease. However, the influences of gender on MP characteristics are not fully understood.Aim: To compare MP characteristics (size, concentration, cellular origin and inflammatory profile) in healthy males and females acros...

Objective: This is a prospective audit looking at cardiovascular parameters in transpeople comparing those who have self medicated verses those who have not.Methods: Patients attending a workshop for new patients were questioned about cardiovascular risk factors including diabetes hypertension and smoking status. Measurements were made of lipid profile, glucose, blood pressure, waist, height and weight measurement. Those that were self medicating (SM) we...

Agranuloctosis is a rare and serious complication of Carbimazole. (risk <1/106 of population/year. It is associated with higher doses. We report two cases over 1 year in patients exposed to amiodarone.Case 1: A 63 year old man with ischemic cardiomyopathy had been treated with amiodarone for atrial fibrillation for 3 years. 6 months after stopping he developed symptomatic thyrotoxicosis and started on carbimazole 60 mg per day. Thyroid T<s...

Objectives: Glycaemic targets set by diabetes teams appear to have an impact on glycaemic control. Our objective was to identify if there is consensus between and within teams in our network on glycaemic targets and whether this correlates with HbA1c outcomes.Methods: An online survey was sent to all network members requesting an independent response on the diabetes self-management advice given to families. Three patient groups were considered: children ...

Hypoparathyroidism, a rare endocrine disorder of insufficient parathyroid hormone, leads to hypocalcemia and often hyperphosphatemia. The PARADOX study assessed the clinical and personal disease impact from the affected patients’ perspective.Patients ≥18 years and diagnosed ≥6 months ago completed a non-validated, self-reported, web-based survey.Three hundred and seventy-four US adults (mean age, 49 years; women, 8...

Introduction: The familial risks of carcinoids are not clear. There has never been a report of gastrointestinal carcinoid coexisting with horseshoe kidney.Case presentation: We present the case of a 15 mm well differentiated metastatic small bowel NET with vascular and perineural invasion and three of four positive lymph nodes (Ki67: 1.9%, ENETS stage: pT4 pN1 pMX R1) in a 75-year-old British male with episodes of diarrhea and 24 h urinary 5HIAA: 48 (&#6...

Prostate cancer development and progression depend on androgen signaling through the androgen receptor (AR). Recent evidence indicates the continued presence of intratumoral dihydrotestosterone (DHT) during androgen deprivation therapy drives prostate cancer recurrence through the activation of AR. There are ongoing efforts to identify drugs that target AR and enzymes that catalyze the synthesis of testosterone and DHT. Temporary remediation of prostate cancer by surgical or m...

Background: With the increasing prevalence of obesity and related morbidity including glucose intolerance in childhood, there remains a dispute about the best screening test to identify this early. The aim of our study was to determine the prevalence of impaired glucose tolerance (IGT)/type 2 diabetes mellitus (T2DM) in a multiethnic cohort of 100 overweight/obese children and adolescents in our clinic and compare the results of the screening tests.Study...

Pituitary MRI is widely used in endocrine practice, and is regarded as entirely safe. We report here a life-threatening outcome from a routine pituitary MRI scan.A 23-year-old female with a 3-year history of microprolactinoma confirmed by MRI underwent a routine repeat MRI scan with gadolinium. During injection of Gadovist she experienced minimal chest tightness which rapidly resolved. Four hours after the injection she rapidly became very breathless. On...